Abstract | BACKGROUND: METHODS AND RESULTS: We determined plasma ADMA levels in 132 men with ED. Patients were divided into a group of 56 men with underlying CAD (ED-CAD) and a group of 76 men without clinical evidence for underlying CAD (ED-No-CAD). Diagnosis of ED was based on the International Index of Erectile Function Score (IIEF-5). Plasma ADMA concentrations in the ED-CAD group were elevated as compared to the ED-No-CAD group, median (IQR): 0.76 (0.65-0.91) micromol/l ADMA vs. 0.49 (0.36-0.71) micromol/l, p < 0.001. In a multiple logistic regression analysis adjusting for hypertension, hypercholesterolemia, low HDL cholesterol and diabetes or fasting glucose > or =6.1 mmol/l, ADMA remained a strong and independent predictor for presence of CAD. Odds ratios for second and third tertiles as compared to lowest tertile of plasma ADMA were 3.3 (95%CI, 1.1-10.3; p = 0.041) and 8.7 (95%CI, 2.8-27.2; p < 0.001), respectively. CONCLUSION: As elevation of ADMA has been found to be associated with many risk factors for both CAD and ED, our data provide further strong evidence for the close interrelation of CAD and ED. Determination of ADMA may help to identify underlying cardiovascular disease in men with ED.
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Authors | Renke Maas, Sven Wenske, Marcus Zabel, Rodolfo Ventura, Edzard Schwedhelm, Anna Steenpass, Hanno Klemm, Joachim Noldus, Rainer H Böger |
Journal | European urology
(Eur Urol)
Vol. 48
Issue 6
Pg. 1004-11; discussion 1011-2
(Dec 2005)
ISSN: 0302-2838 [Print] Switzerland |
PMID | 16139418
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers
- dimethylarginine
- Arginine
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Topics |
- Age Distribution
- Aged
- Arginine
(analogs & derivatives, analysis, blood)
- Biomarkers
(blood)
- Case-Control Studies
- Comorbidity
- Confidence Intervals
- Coronary Artery Disease
(blood, diagnosis, epidemiology)
- Erectile Dysfunction
(diagnosis, epidemiology)
- Humans
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio
- Prevalence
- Prognosis
- Risk Assessment
- Sensitivity and Specificity
- Severity of Illness Index
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