The treatment of urinary incontinence in children using glutaraldehyde cross-linked collagen.

Abstract

Periurethral injection of polytetrafluoroethylene (PolyTef) paste has been used to correct urinary incontinence for 2 decades. The controversy over distant migration of the paste has led to an interest in alternative materials particularly for the pediatric patient. Glutaraldehyde cross-linked collagen, derived from bovine dermal collagen, is effective in treating urinary incontinence in adults. Eight children with structural urinary incontinence underwent glutaraldehyde cross-linked collagen injection. Fluorourodynamic studies preceded and followed the injections. An average of 10.9 cc glutaraldehyde cross-linked collagen was injected per treatment (range 2.5 to 20). The number of injections per child ranged from 1 to 6 (mean 2.1) and followup averaged 13.75 months (range 6 to 33). Overall, 88% of the patients were cured or improved: 5 (63%) became continent, 2 were improved and 1 had no effect.

• Authors: J Wan, E J McGuire, D A Bloom, M L Ritchey
• Journal: The Journal of urology (J Urol) Vol. 148 Issue 1 Pg. 127-30 (Jul 1992) ISSN: 0022-5347 [Print] United States
• PMID: 1613852 (Publication Type: Journal Article)

Chemical References

• Cross-Linking Reagents
• Collagen
• Glutaral

Topics

• Adolescent
• Child
• Collagen (administration & dosage)
• Cross-Linking Reagents (administration & dosage)
• Female
• Follow-Up Studies
• Glutaral (administration & dosage)
• Humans
• Injections
• Male
• Prostheses and Implants
• Urinary Incontinence (therapy)