Abstract | OBJECTIVES: METHODS: Subjects received posaconazole oral suspension 800 mg/day in divided doses for up to 1 year; however, subjects could receive additional therapy as part of a treatment-use extension protocol. A blinded, third-party data review committee determined subject eligibility and outcome. RESULTS: Of the 330 subjects who enrolled in the study, 53 had infections of the CNS, of which 39 were considered evaluable for efficacy. Most had refractory disease (37 of 39) and underlying HIV infection (29 of 39). Twenty-nine subjects had cryptococcal infections, and 10 had infections caused by other fungal pathogens [Aspergillus spp. (four), Pseudallescheria boydii (two), Coccidioides immitis (one), Histoplasma capsulatum (one), Ramichloridium mackenziei (one), and Apophysomyces elegans plus a Basidiomycetes sp. (one)]. Successful outcomes were observed in 14 of 29 (48%) subjects with cryptococcal meningitis and five of 10 (50%) subjects with CNS infections due to other fungal pathogens. Posaconazole was well tolerated. CONCLUSIONS:
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Authors | Punnee Pitisuttithum, Ricardo Negroni, John R Graybill, Beatriz Bustamante, Peter Pappas, Stanley Chapman, Roberta S Hare, Catherine J Hardalo |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 56
Issue 4
Pg. 745-55
(Oct 2005)
ISSN: 0305-7453 [Print] England |
PMID | 16135526
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Triazoles
- posaconazole
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Topics |
- Adolescent
- Adult
- Antifungal Agents
(adverse effects, therapeutic use)
- Central Nervous System Fungal Infections
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Salvage Therapy
- Treatment Outcome
- Triazoles
(adverse effects, therapeutic use)
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