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Varicella zoster virus acute retinal necrosis following eye contusion: case report.

AbstractBACKGROUND:
Acute retinal necrosis is a sight-threatening disease caused by the group of herpesviruses. The aim of this paper is to report a case of acute retinal necrosis following ocular trauma in a patient initially treated with vaso-active drugs and corticosteroids for presumed ocular ischemic syndrome.
CASE PRESENTATION:
A 51-years-old otherwise healthy man, who suffered from sudden visual loss in the left eye following contusion, was commenced on vaso-active drugs and systemic corticosteroids for suspected ocular ischemic syndrome with extensive swelling of the optic disc and macular edema. Subsequently, vision in the initially uninvolved right eye decreased. Polymerase chain reaction of vitreous samples and retinal biopsy confirmed varicella zoster virus. Despite intensive treatment with intravenous antiviral medication, the patient became completely blind in both eyes.
CONCLUSION:
Initial treatment of acute, unexplained visual decrease with systemic corticosteroids may lead to visual loss in patients with developing acute retinal necrosis. Ocular trauma could have induced and corticosteroid treatment promoted reactivation of a latent viral infection in our patient.
AuthorsPetra Svozílková, Eva Ríhová, Pavel Diblík, Pavel Kuthan, Zdenek Kovarík, Bohdana Kalvodová
JournalVirology journal (Virol J) Vol. 2 Pg. 77 (Aug 31 2005) ISSN: 1743-422X [Electronic] England
PMID16135256 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Adrenal Cortex Hormones
  • Antiviral Agents
  • Vasoconstrictor Agents
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Animals
  • Antiviral Agents (therapeutic use)
  • Contusions (complications)
  • Eye Injuries (complications)
  • Herpes Zoster (diagnosis, virology)
  • Herpesvirus 3, Human (isolation & purification)
  • Humans
  • Male
  • Middle Aged
  • Retinal Necrosis Syndrome, Acute (virology)
  • Vasoconstrictor Agents (therapeutic use)
  • Virus Latency

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