Abstract |
Successful pharmacotherapy of pituitary hormonal excess is established only in the treatment of acromegaly ( dopamine agonists, somatostatin analogues, GH-receptor-antagonists) and of prolactinomas ( dopamine agonists). Gold standard in the treatment of acromegaly is transsphenoidal pituitary surgery, while in prolactinomas, surgery is indicated only in exceptional cases. Substitution of pituitary insufficiency offers the patients a normal quality of life. Substitution of the cortico- and thyrotrope axis with hydrocortisone and levothyroxine is vital. In women, substitution of the gonadotrope axis should be performed up to menopause ( estrogen/ gestagen). In men, substitution should be performed lifelong (trans-dermal testosterone body patches, testosterone gel, testosterone undecanoate/enanthate). To achieve fertility, gonadotropins or pulsatile GnRH therapy has very good results. Especially in younger patients, substitution of growth hormone may be useful ( somatropin).
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Authors | B Gutt, B Steffin, J Schopohl |
Journal | Der Internist
(Internist (Berl))
Vol. 46
Issue 10
Pg. 1158-65
(Oct 2005)
ISSN: 0020-9554 [Print] Germany |
Vernacular Title | Medikamentöse Therapie von Hypophysenerkrankungen. |
PMID | 16133220
(Publication Type: English Abstract, Journal Article, Review)
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Chemical References |
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Topics |
- Hormone Replacement Therapy
(methods)
- Hormones
(therapeutic use)
- Humans
- Pituitary Diseases
(drug therapy)
- Practice Guidelines as Topic
- Practice Patterns, Physicians'
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