Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia.

Abstract

The vesicular monoamine transporter (VMAT2) is important in the storage and release of monoamines. Platelet VMAT2 was characterized using high-affinity [(3)H]dihydrotetrabenazine ([(3)H]TBZOH) binding in untreated social phobia (SP) patients (n=20) compared with sex- and age-matched healthy controls (n=15). No significant differences in VMAT2 density (B(max)) and affinity constants (K(d)) were observed.

• Authors: Neil Laufer, Michal Zucker, Haggai Hermesh, Sofi Marom, Royi Gilad, Vered Nir, Abraham Weizman, Moshe Rehavi
• Journal: Psychiatry research (Psychiatry Res) Vol. 136 Issue 2-3 Pg. 247-50 (Sep 15 2005) ISSN: 0165-1781 [Print] Ireland
• PMID: 16129496 (Publication Type: Journal Article)

Chemical References

• SLC18A2 protein, human
• Vesicular Monoamine Transport Proteins
• dihydrotetrabenazine
• Tetrabenazine

Topics

• Adult
• Blood Platelets (cytology, metabolism)
• Cell Count
• Female
• Humans
• Male
• Phobic Disorders (diagnosis, metabolism)
• Surveys and Questionnaires
• Tetrabenazine (analogs & derivatives, pharmacokinetics)
• Vesicular Monoamine Transport Proteins (blood, metabolism)