Abstract | PURPOSE: MATERIAL AND METHODS: The study comprised 15 dry eye syndrome patients (30 eyes), who were divided into three groups. In Group I were those with severe aggravation of dry eye syndrome manifestations without concomitant systemic diseases (3 women), aged 54 to 59 years (mean 57). Group II comprised the patients with Sjogren's syndrome (8 women, 1 man), aged 45 to 59 years (mean 55.5) with graft versus host disease. In Group III, there were 3 women, aged 52 to 59 years (mean 55) with graft versus host disease. All the patients were administered 0.05% cyclosporine topically twice daily. The Group I patients were given 0.05% cyclosporine solution for 3 months, those in Groups II and III for 6 months. Subjective complaints were classified according to the protocol of Dr. Mann Pharma/Bausch & Lomb. RESULTS: The effectiveness of the therapy with 0.05% cyclosporine solution was evaluated by the mean number of points in a five-point Schirmer II test score, measured before and after the treatment. The Group I patients ( dry eye syndrome without systemic diseases) were found to have the highest mean number of points - 4. In the Sjogren's syndrome Group, the mean number of points was 3.1; and in Group III ( graft vs host disease) the mean value was 2 points. Since the number of patients was different in particular groups, the findings have not been compared between themselves. CONCLUSIONS:
|
Authors | Agnieszka Kujawa, Radosław Rózycki |
Journal | Klinika oczna
(Klin Oczna)
Vol. 107
Issue 4-6
Pg. 280-6
( 2005)
ISSN: 0023-2157 [Print] Poland |
Vernacular Title | Leczenie zaawansowanych przypadków zespołu suchego oka 0,05% roztworem cyklosporyny. |
PMID | 16118939
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Immunosuppressive Agents
- Cyclosporine
|
Topics |
- Administration, Topical
- Bone Marrow Transplantation
(adverse effects)
- Cyclosporine
(administration & dosage)
- Dry Eye Syndromes
(drug therapy, physiopathology)
- Female
- Graft vs Host Disease
(complications)
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Male
- Middle Aged
- Sjogren's Syndrome
(complications)
- Time Factors
- Treatment Outcome
|