[Efficacy of and tolerance to combined therapy with dihydropyridine and non-dihydropyridine Ca antagonists in patients with moderate arterial hypertension].

Abstract

The authors of the article studied efficacy of combined therapy with dihydropyridine and non-dihydropyridine Ca antagonists, its influence on structural and functional condition of the heart in 53 patients (28 men and 25 women) with moderate arterial hypertension (AH), and their tolerance to the therapy. Before and during the treatment the patients underwent 24-hour arterial pressure (AP) monitoring and Doppler echoCG. Due to combined therapy with isoptin SR and corinfar retard complete hypotensive effect (AP < 140/90 mmHg) was achieved in 83% of cases, and partial effect (diastolic pressure lowered by 10 mmHg)--in 17%. The therapy significantly reduced left ventricular mass index (14.6% on the average; p < 0.01), and improved diastolic function: E/A increased by 10.3% (p < 0.05), and isovolumetric relaxation time decreased by 13.6% (p < 0.01). Combined therapy also resulted in a 1.5 to 4 time reduction in the frequency of side effects of isoptin SR and corinfar retard due to reduction in their doses and/or mutual neutralization of their side effects. The paper demonstrates high antihypertensive efficacy of and good tolerance to the combination of dihydropyridines and non-dihydropyridines when they are administered for prolonged therapy in patients with moderate AH.

• Authors: B G Iskenderov, L F Burmistrova, T N Vakina, T V Lokhina, S R Bogdanova
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 83 Issue 7 Pg. 37-40 ( 2005) ISSN: 0023-2149 [Print] Russia (Federation)
• PMID: 16117423 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Calcium Channel Blockers
• Verapamil
• Nifedipine

Topics

• Adult
• Aged
• Blood Pressure (drug effects, physiology)
• Blood Pressure Monitoring, Ambulatory
• Calcium Channel Blockers (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Drug Interactions
• Drug Therapy, Combination
• Echocardiography, Doppler
• Female
• Follow-Up Studies
• Humans
• Hypertension (complications, drug therapy, physiopathology)
• Hypertrophy, Left Ventricular (complications, diagnostic imaging, physiopathology)
• Male
• Middle Aged
• Myocardial Contraction (physiology)
• Nifedipine (administration & dosage, therapeutic use)
• Severity of Illness Index
• Time Factors
• Treatment Outcome
• Verapamil (administration & dosage, therapeutic use)