Abstract |
Stroke is the leading cause of severe disability and the third leading cause of death, accounting for one of every 15 deaths in the USA. We investigated the association of polymorphisms in the soluble epoxide hydrolase gene (EPHX2) with incident ischemic stroke in African-Americans and Whites. Twelve single nucleotide polymorphisms (SNPs) spanning EPHX2 were genotyped in a case-cohort sample of 1336 participants from the Atherosclerosis Risk in Communities (ARIC) study. In each racial group, Cox proportional hazard models were constructed to assess the relationship between incident ischemic stroke and EPHX2 polymorphisms. A score test method was used to investigate the association of common haplotypes of the gene with risk of ischemic stroke. In African-Americans, two common EPHX2 haplotypes with significant and opposing relationships to ischemic stroke risk were identified. In Whites, two common haplotypes showed suggestive indication of an association with ischemic stroke risk but, as in African-Americans, these relationships were in opposite direction. These findings suggest that multiple variants exist within or near the EPHX2 gene, with greatly contrasting relationships to ischemic stroke incidence; some associated with a higher incidence and others with a lower incidence.
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Authors | Myriam Fornage, Craig R Lee, Peter A Doris, Molly S Bray, Gerardo Heiss, Darryl C Zeldin, Eric Boerwinkle |
Journal | Human molecular genetics
(Hum Mol Genet)
Vol. 14
Issue 19
Pg. 2829-37
(Oct 01 2005)
ISSN: 0964-6906 [Print] England |
PMID | 16115816
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Epoxide Hydrolases
- EPHX2 protein, human
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Topics |
- Black or African American
(genetics)
- Base Sequence
- Brain Ischemia
(epidemiology, ethnology, genetics)
- Epoxide Hydrolases
(genetics)
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
- Stroke
(epidemiology, ethnology, genetics)
- White People
(genetics)
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