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Search for melanoma markers in plasma and serum samples.

Abstract
Fourteen blood samples from patients with melanoma and eleven blood samples from healthy subjects were analyzed by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. The study was focussed on species of low molecular weight, in the range 800-5000 Da, present in plasma and sera. While for healthy subjects plasma samples lead to the production of a higher number of ionic species, for melanoma patients a high number of diagnostic ions, present with high frequency and with quite high relative abundance, are present in particular in serum samples and to a lesser extent also in plasma. Since plasma samples are obtained more easily in comparison to sera, it is possible to suggest that also plasma can be used for these studies.
AuthorsRoberta Seraglia, Susanna Vogliardi, Graziella Allegri, Stefano Comai, Mario Lise, Carlo Ricardo Rossi, Simone Mocellin, Romano Scalerta, Eugenio Ragazzi, Pietro Traldi
JournalEuropean journal of mass spectrometry (Chichester, England) (Eur J Mass Spectrom (Chichester)) Vol. 11 Issue 3 Pg. 353-60 ( 2005) ISSN: 1469-0667 [Print] England
PMID16107750 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
Topics
  • Adult
  • Aged
  • Biomarkers, Tumor (blood)
  • Calibration
  • Female
  • Humans
  • Male
  • Melanoma (blood)
  • Middle Aged
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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