Abstract |
Fourteen blood samples from patients with melanoma and eleven blood samples from healthy subjects were analyzed by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. The study was focussed on species of low molecular weight, in the range 800-5000 Da, present in plasma and sera. While for healthy subjects plasma samples lead to the production of a higher number of ionic species, for melanoma patients a high number of diagnostic ions, present with high frequency and with quite high relative abundance, are present in particular in serum samples and to a lesser extent also in plasma. Since plasma samples are obtained more easily in comparison to sera, it is possible to suggest that also plasma can be used for these studies.
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Authors | Roberta Seraglia, Susanna Vogliardi, Graziella Allegri, Stefano Comai, Mario Lise, Carlo Ricardo Rossi, Simone Mocellin, Romano Scalerta, Eugenio Ragazzi, Pietro Traldi |
Journal | European journal of mass spectrometry (Chichester, England)
(Eur J Mass Spectrom (Chichester))
Vol. 11
Issue 3
Pg. 353-60
( 2005)
ISSN: 1469-0667 [Print] England |
PMID | 16107750
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(blood)
- Calibration
- Female
- Humans
- Male
- Melanoma
(blood)
- Middle Aged
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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