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Evaluation of antipyretic activity of Calotropis gigantea (Asclepiadaceae) in experimental animals.

Abstract
The roots of Calotropis gigantea have been used in leprosy, eczema, syphilis, elephantiasis, ulceration and cough in the Indian system of traditional medicine. The present communication evaluated its antipyretic activity by using yeast-induced and TAB (Typhoid) vaccine-induced pyrexia in rats and rabbits. In both yeast-induced and TAB vaccine-induced fever, the fever was significantly reduced and the body temperature was normalized by administration of 200 and 400 mg/kg dose intraperitoneally. Based on the results of the present study it can be concluded that the extract of C. gigantea has potential antipyretic activity against both yeast-induced and TAB vaccine-induced fever, indicating the possibility of developing C. gigantea as a cheaper and potent antipyretic agent.
AuthorsH R Chitme, Ramesh Chandra, Sadhna Kaushik
JournalPhytotherapy research : PTR (Phytother Res) Vol. 19 Issue 5 Pg. 454-6 (May 2005) ISSN: 0951-418X [Print] England
PMID16106390 (Publication Type: Journal Article)
CopyrightCopyright (c) 2005 John Wiley & Sons, Ltd.
Chemical References
  • Analgesics, Non-Narcotic
  • Plant Extracts
  • Typhoid-Paratyphoid Vaccines
Topics
  • Analgesics, Non-Narcotic (administration & dosage, pharmacology, therapeutic use)
  • Animals
  • Calotropis
  • Female
  • Fever (etiology, prevention & control)
  • Male
  • Mice
  • Phytotherapy
  • Plant Components, Aerial
  • Plant Extracts (administration & dosage, pharmacology, therapeutic use)
  • Rabbits
  • Rats
  • Typhoid-Paratyphoid Vaccines
  • Yeasts

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