Abstract | BACKGROUND: METHODS: RESULTS: Mean urinary oxalate excretion fell by 19% after 1 month (1 dose per day, P < 0.05), and oxalate excretion remained reduced by 24% during the second month (2 doses per day, P < 0.05). During the third month on 3 doses per day oxalate excretion increased slightly, so that the mean was close to the baseline established off treatment. Urinary oxalate again fell 20% from baseline during the washout period. Calcium oxalate supersaturation was reduced while on Oxadrop, largely due to the decrease in oxalate excretion, although mean changes did not reach statistical significance. CONCLUSION: Manipulation of gastrointestinal (GI) flora can influence urinary oxalate excretion to reduce urinary supersaturation levels. These changes could have a salutary effect on stone formation rates. Further studies will be needed to establish the optimal dosing regimen.
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Authors | John C Lieske, David S Goldfarb, Claudio De Simone, Cynthia Regnier |
Journal | Kidney international
(Kidney Int)
Vol. 68
Issue 3
Pg. 1244-9
(Sep 2005)
ISSN: 0085-2538 [Print] United States |
PMID | 16105057
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Aged
- Bifidobacterium
- Humans
- Hyperoxaluria
(etiology, therapy, urine)
- Intestines
(microbiology)
- Kidney Calculi
(etiology, prevention & control)
- Lactobacillus acidophilus
- Levilactobacillus brevis
- Malabsorption Syndromes
(complications)
- Male
- Middle Aged
- Oxalates
(urine)
- Probiotics
(administration & dosage, adverse effects)
- Streptococcus thermophilus
- Treatment Outcome
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