HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Efficacy of myrrh in the treatment of human Schistosomiasis mansoni.

Abstract
Myrrh (Mirazid) has been produced and marketed as an antischistosomal drug since 2001. The current study was designed to assess the efficacy of a commercially available product of myrrh. One hundred four individuals, infected with Schistosoma mansoni, were randomized in two groups, one for myrrh and the second for praziquantel. Treatment-whether myrrh or praziquantel-was given twice with a 3-week interval. The cure rate with myrrh was very low, 15.6% after the first treatment, and 8.9% after the second treatment. Egg reduction among uncured persons was also very low, being 17.2% after the first treatment, and 28% after the second treatment. Praziquantel cure rate was 73.7% and 76.3%, and individuals still passing S. mansoni ova after praziquantel treatment showed a substantial reduction in the geometric mean egg counts (84% and 88.2% after the first and second treatments, respectively). When 34 individuals-uncured after two myrrh treatments-were offered praziquantel in the standard dose, 32 of them stopped passing S. mansoni eggs when tested 4 weeks post-treatment. The results of the current study raise serious doubts about the antischistosomal properties of Mirazid.
AuthorsRashida Barakat, Hala Elmorshedy, Alan Fenwick
JournalThe American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 73 Issue 2 Pg. 365-7 (Aug 2005) ISSN: 0002-9637 [Print] United States
PMID16103605 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anthelmintics
  • Schistosomicides
  • Terpenes
  • Praziquantel
  • myrrh oil
Topics
  • Adolescent
  • Adult
  • Animals
  • Anthelmintics (therapeutic use)
  • Female
  • Humans
  • Male
  • Parasite Egg Count
  • Praziquantel (therapeutic use)
  • Schistosoma mansoni (drug effects)
  • Schistosomiasis mansoni (drug therapy, parasitology)
  • Schistosomicides (pharmacology, therapeutic use)
  • Terpenes (pharmacology, therapeutic use)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: