Abstract | OBJECTIVE: METHODS: RESULTS: The preoperative level of soluble FM- fibrinogen complex showed variation in the degree of hemostatic activation, with fair correlations with TAT (r = 0.509, P < .001), D-dimer (r = 0.521, P < .001), and PIC (r = 0.579, P < .001). The patients with greater intraoperative blood loss (> or = 800 mL) showed a significantly elevated plasma level of soluble FM- fibrinogen complex preoperatively compared with those with less intraoperative blood loss (P = .009). Its postoperative fluctuation showed a similar pattern to that of TAT, reflecting the time course of coagulation activity. Gelatin impregnation of the Dacron vascular graft did not seem to influence the postoperative systemic coagulation mechanism. CONCLUSIONS: The results indicated that soluble FM- fibrinogen complex appears to be a useful diagnostic molecular marker to assess the activity of the coagulation system, and that its preoperative level may serve as a potential risk factor for intraoperative hemorrhagic diathesis in patients undergoing elective AAA repair.
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Authors | Akihiro Hosaka, Tetsuro Miyata, Haruo Aramoto, Hiroshi Shigematsu, Tatsu Nakazawa, Hiroyuki Okamoto, Kunihiro Shigematsu, Hirokazu Nagawa |
Journal | Journal of vascular surgery
(J Vasc Surg)
Vol. 42
Issue 2
Pg. 200-5
(Aug 2005)
ISSN: 0741-5214 [Print] United States |
PMID | 16102614
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Fibrin Fibrinogen Degradation Products
- antithrombin III-protease complex
- fibrin fragment D
- fibrinmonomer
- Antithrombin III
- Peptide Hydrolases
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Topics |
- Aged
- Antithrombin III
- Aortic Aneurysm, Abdominal
(blood, surgery)
- Biomarkers
(blood)
- Blood Loss, Surgical
- Blood Vessel Prosthesis Implantation
- Female
- Fibrin Fibrinogen Degradation Products
(analysis)
- Humans
- Latex Fixation Tests
- Male
- Peptide Hydrolases
(blood)
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