Recurrent pancreatitis after trimethoprim-sulfamethoxazole rechallenge.

Abstract

We report a female patient who repeatedly developed pancreatitis after trimethoprim-sulfamethoxazole (TMP/SMX) use. During childhood she had undergone an ureterosigmoidostomy after which she had been on TMP/SMX 480 mg daily as prophylaxis for pyelonephritis for many years. The patient presented with abdominal pain caused by acute pancreatitis. No other cause, except for TMP/SMX use, could be identified. A causal relationship was confirmed by relapse of the pancreatitis after rechallenge. Our case is unique in demonstrating that acute pancreatitis related to the use of TMP/SMX may occur even after long-term treatment. We advise that the medication is discontinued immediately if a causal relationship with pancreatitis is suspected.

• Authors: M W J Versleijen, A H J Naber, N P Riksen, G J Wanten, F M J Debruyne
• Journal: The Netherlands journal of medicine (Neth J Med) 2005 Jul-Aug Vol. 63 Issue 7 Pg. 275-7 ISSN: 0300-2977 [Print] Netherlands
• PMID: 16093580 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Infective Agents, Urinary
• Trimethoprim, Sulfamethoxazole Drug Combination

Topics

• Anti-Infective Agents, Urinary (adverse effects, therapeutic use)
• Endoscopy, Gastrointestinal
• Female
• Follow-Up Studies
• Humans
• Middle Aged
• Pancreatitis, Acute Necrotizing (chemically induced, diagnosis)
• Pyelonephritis (prevention & control)
• Recurrence
• Time Factors
• Trimethoprim, Sulfamethoxazole Drug Combination (adverse effects, therapeutic use)