A clinical comparison of two different prednisolone acetate formulations in patients undergoing cataract surgery.

Abstract

PURPOSE:

This study was conducted to evaluate the efficacy of two topical steroid prednisolone preparations (Econopred Plus 1%, prednisolone acetate 1%: EPP; Pred Fortedagger 1%, prednisolone acetate 1%: PF) in reducing postoperative inflammation in cataract patients.

METHODS:

This was a 4 week, randomized, parallel-group, single-center, active-controlled study. One group of patients received postoperative topical EPP while the other group received postoperative topical PF. Both medications were dosed 4 times per day for 14 days and then BID until the container was empty. Both groups of patients received diclofenac sodium QID for 14 days and hydroxypropyl guar (HP-Guar, Systane) QID for 7 days then PRN (or as directed). The presence of corneal surface keratitis, anterior chamber cells and flare (scales 0-3 for keratitis, 0-5 for cells and 0-4 for flare; 0 = none) was evaluated by slit lamp biomicroscopy.

RESULTS:

EPP produced significantly lower (P < 0.05) anterior chamber flare scores 14 days following surgery (mean +/- SD: 0.86 +/- 0.53) than PF (1.08 +/- 0.40). Otherwise, there were no differences observed between the 2 treatments with respect to keratitis, anterior chamber flare or cells at postop days 1, 7, or 28.

CONCLUSIONS:

This comparative trial demonstrated that both formulations of prednisolone acetate 1% have similar efficacy in the treatment of postoperative ophthalmologic inflammation.

• Authors: Johnny L Gayton
• Journal: Current medical research and opinion (Curr Med Res Opin) Vol. 21 Issue 8 Pg. 1291-5 (Aug 2005) ISSN: 0300-7995 [Print] England
• PMID: 16083539 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Glucocorticoids
• prednisolone acetate
• Prednisolone

Topics

• Aged
• Cataract Extraction (adverse effects)
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Inflammation (etiology, prevention & control)
• Lens Implantation, Intraocular (adverse effects)
• Macular Edema (etiology, prevention & control)
• Male
• Postoperative Care
• Prednisolone (analogs & derivatives, therapeutic use)
• Treatment Outcome