Comparative study of 2% ketoconazole cream and 1% hydrocortisone cream in the treatment of infantile seborrheic dermatitis.

Abstract

OBJECTIVE:

To compare efficacy of 2% ketoconazole cream with 1% hydrocortisone cream in the treatment of infantile seborrheic dermatitis (ISD). This study recruited infants of 2 weeks to 2 years old with a clinical diagnosis of infantile seborrheic at the Department of Pediatrics, King Chulalongkorn Memorial Hospital from December 2001 to November 2003.

METHOD:

The severity of the rash of the patients was examined in terms of erythema, scale and crust before treatment based on a scoring system comparing two sides (left and right) of the lesion with numeral representation for it a severity, namely: Ofor no lesion; 1, mild; 2, moderate; and 3, severe. They were treated with 2% ketoconazole cream on the left side of the lesion and 1% hydrocortisone cream on the right side of the lesion, twice a day.

RESULTS:

The responses of treatment of 2% ketoconazole cream compared with 1% hydrocortisone cream in 48 patients had no statistical significant difference at 2-3 days of treatment and 4-7 days of treatment. By one week, both 2% ketoconazole cream and 1% hydrocortisone cream have significant clinical improvement of the lesion. The skin lesions were cleared in 31% of the ketoconazole group and 35% of the hydrocortisone group. All skin lesions were cleared by the end of the second week.

CONCLUSION:

The efficacy of 2% ketoconazole cream and 1% hydrocortisone cream in the treatment of ISD was not significantly different. Ketoconazole is another option for the treatment of ISD, to avoid the side effects of topical corticosteroid in long-term use and on large surface area of treatment.

• Authors: Siriwan Wannanukul, Jutamas Chiabunkana
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 87 Suppl 2 Pg. S68-71 (Sep 2004) ISSN: 0125-2208 [Print] Thailand
• PMID: 16083165 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antifungal Agents
• Ointments
• Ketoconazole
• Hydrocortisone

Topics

• Adolescent
• Anti-Inflammatory Agents (administration & dosage)
• Antifungal Agents (administration & dosage)
• Child
• Child, Preschool
• Dermatitis, Seborrheic (drug therapy)
• Female
• Humans
• Hydrocortisone (administration & dosage)
• Infant
• Ketoconazole (administration & dosage)
• Male
• Ointments
• Treatment Outcome