Abstract |
Liver transplantation (LTX) corrects the enzymatic defect responsible for type 1 primary hyperoxaluria (PH1). It has been advocated in combination with kidney transplantation (KTX) in patients with renal failure from PH1 because KTX alone can result in early graft loss. A 58-year-old male patient with PH1 on hemodialysis underwent resection of the left lateral segment of the liver followed by orthotopic auxiliary left lateral segment liver transplantation and kidney transplantation from a deceased donor. The serum oxalate dropped from 34.8 micromol/L before transplant to 3.6-8.3 in the first months posttransplant to <1 micromol/L (normal range 0.4-3.0). One year after posttransplant, the patient has an iothalamate glomerular filtration rate of 58 ml/min. Orthotopic auxiliary LTX is an alternative to whole LTX in PH1. By using a split deceased donor liver, it does not deprive the donor pool and protects the recipient from liver failure in case of graft loss.
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Authors | Nicholas Onaca, Edmund Q Sanchez, Larry B Melton, George J Netto, Karl A Glastad, Patriciu A Martin, Takehisa Ueno, Marlon F Levy, Robert M Goldstein, Goran B Klintmalm |
Journal | Transplantation
(Transplantation)
Vol. 80
Issue 3
Pg. 421-4
(Aug 15 2005)
ISSN: 0041-1337 [Print] United States |
PMID | 16082341
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Oxalates
- Transaminases
- Alanine-glyoxylate transaminase
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Topics |
- Cadaver
- DNA Mutational Analysis
- Glomerular Filtration Rate
- Graft Rejection
- Graft Survival
- Humans
- Hyperoxaluria, Primary
(therapy)
- Kidney Transplantation
(methods)
- Liver
(anatomy & histology, pathology)
- Liver Transplantation
(methods)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Oxalates
(blood)
- Renal Dialysis
- Time Factors
- Tissue Donors
- Transaminases
(genetics)
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