Abstract | OBJECTIVE: METHODS: RESULTS: The amount of NO in the L-Arg group was higher than in the control group, while in the L-NAME group was lower than in the control group (P < 0.05). The peak of serum CINC concentration occurred 3 hours after reperfusion with significant difference among groups. Expression peak of CINC mRNA in the pancreas graft occurred 3 hours after reperfusion. The expression level in the L-Arg group was lower than in the control group, the L-NAME group was higher than control group (P < 0.05). MPO activity in the L-Arg group obviously decreasd compared with other groups. The pancreas inflammation was ameliorated in L-Arg group, and pancreas damage was aggravated in L-NAME group. CONCLUSIONS: L-Arg can increase the amount of NO and inhibit the elevation of CINC, CINC mRNA expression, and early neutrophil accumulation in the transplanted pancreas. NO has protective effects on the ischemia/reperfusion injury of pancreaticoduodenal transplantation.
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Authors | Chun-hui Yuan, Yong-feng Liu, Jian Liang, Ning Zhao, San-guang He |
Journal | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
(Chin Med Sci J)
Vol. 20
Issue 2
Pg. 142-6
(Jun 2005)
ISSN: 1001-9294 [Print] China |
PMID | 16075760
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chemokines, CXC
- RNA, Messenger
- Nitric Oxide
- Arginine
- Peroxidase
- NG-Nitroarginine Methyl Ester
|
Topics |
- Animals
- Arginine
(pharmacology)
- Chemokines, CXC
(biosynthesis, genetics)
- Duodenum
(transplantation)
- Male
- NG-Nitroarginine Methyl Ester
(pharmacology)
- Nitric Oxide
(metabolism)
- Pancreas Transplantation
- Peroxidase
(metabolism)
- RNA, Messenger
(biosynthesis, genetics)
- Rats
- Rats, Wistar
- Reperfusion Injury
(metabolism)
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