HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pleural phenol therapy for the treatment of chronic esophageal cancer pain.

AbstractBACKGROUND AND OBJECTIVES:
Pleural phenol was used successfully to alleviate terminal pain associated with metastatic esophageal cancer in a 43-year-old man.
METHODS:
The patient first was given 20 ml 0.5% bupivacaine for diagnostic purposes through an interpleural catheter to control a severe aching pain throughout the T5-8 dermatomes. Seven days later, 10 ml 6% phenol suspended in 0.5% bupivacaine was injected and produced analgesia for two days. A second injection using 18 ml 10% phenol provided adequate analgesia for the next four weeks until the patient's death. Two weeks after the lower thoracic pain was relieved, the patient had complained of a new right-sided pain in the region of C7-T2, which was treated successfully with 10 ml 10% phenol.
RESULTS:
During the course of this therapy, his sustained-release morphine consumption diminished from 540 mg to 90 mg despite his terminal disease. Post mortem examination and histologic studies revealed no macroscopic or microscopic changes to the viscera, spinal cord, or sympathetic chain.
CONCLUSIONS:
Repeated doses of phenol suspended in bupivacaine provide adequate analgesia for terminal cancer pain when administered interpleurally. No pathologic changes were detected despite a total of 3400 mg phenol delivered into the right thoracic cavity.
AuthorsM J Lema, D P Myers, O De Leon-Casasola, R Penetrante
JournalRegional anesthesia (Reg Anesth) 1992 May-Jun Vol. 17 Issue 3 Pg. 166-70 ISSN: 0146-521X [Print] United States
PMID1606100 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Phenols
Topics
  • Adult
  • Chronic Disease
  • Esophageal Neoplasms (physiopathology)
  • Humans
  • Male
  • Pain (drug therapy, etiology)
  • Phenols (administration & dosage, therapeutic use)
  • Pleura

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: