Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.

Abstract

The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime which reactivated GF inhibited acetylcholinesterase. This might explain the reason why the HI-6 treated mice appeared to recover more quickly from the incapacitating effects following GF poisoning.

• Authors: J G Clement
• Journal: Archives of toxicology (Arch Toxicol) Vol. 66 Issue 2 Pg. 143-4 ( 1992) ISSN: 0340-5761 [Print] Germany
• PMID: 1605730 (Publication Type: Journal Article)

Chemical References

• Antidotes
• Chemical Warfare Agents
• Cholinesterase Reactivators
• Organophosphorus Compounds
• Oximes
• Pralidoxime Compounds
• Pyridinium Compounds
• Obidoxime Chloride
• Atropine
• asoxime chloride
• pralidoxime
• cyclohexyl methylphosphonofluoridate

Topics

• Animals
• Antidotes (therapeutic use)
• Atropine (therapeutic use)
• Chemical Warfare Agents (poisoning)
• Cholinesterase Reactivators (therapeutic use)
• In Vitro Techniques
• Lethal Dose 50
• Male
• Mice
• Mice, Inbred Strains
• Nervous System Diseases (chemically induced, prevention & control)
• Obidoxime Chloride (therapeutic use)
• Organophosphate Poisoning
• Organophosphorus Compounds (analysis)
• Oximes (therapeutic use)
• Pralidoxime Compounds (therapeutic use)
• Pyridinium Compounds (therapeutic use)