HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Stress proteins in Alzheimer's disease.

Abstract
Environmental and genetic conditions can cause proteins to misfold or to accumulate abnormally due to impaired clearance. The chaperones which include heat shock proteins, aid survival by preventing protein mis-folding and the formation of cytotoxic protein aggregates. An increasing number of studies point to important roles for molecular chaperones in the biology of neurodegenerative diseases. Heat shock proteins can suppress neurotoxicity in animal models of Parkinson's and polyglutamine diseases, suggesting potential new therapeutic approaches in neurodegenerative disorders associated with abnormal protein folding and toxicity. Recent findings suggest that heat shock proteins can also be neuroprotective in Alzheimer's disease, but this area of research remains largely unexplored. This paper will review the literature related to the role of heat shock proteins in Alzheimer's disease.
AuthorsR C Smith, K M Rosen, R Pola, J Magrané
JournalInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (Int J Hyperthermia) Vol. 21 Issue 5 Pg. 421-31 (Aug 2005) ISSN: 0265-6736 [Print] England
PMID16048839 (Publication Type: Journal Article, Review)
Chemical References
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • CRYAB protein, human
  • HSP27 Heat-Shock Proteins
  • HSPB1 protein, human
  • Heat-Shock Proteins
  • Intermediate Filament Proteins
  • Molecular Chaperones
  • Neoplasm Proteins
  • Nerve Tissue Proteins
  • Ubiquitin
  • alpha-Crystallin B Chain
  • tau Proteins
  • Protein Kinases
Topics
  • Alzheimer Disease (metabolism, physiopathology)
  • Amyloid beta-Peptides (metabolism)
  • Amyloid beta-Protein Precursor (metabolism)
  • HSP27 Heat-Shock Proteins
  • Heat-Shock Proteins (chemistry, metabolism, physiology)
  • Humans
  • Intermediate Filament Proteins (metabolism)
  • Molecular Chaperones
  • Neoplasm Proteins (metabolism)
  • Nerve Tissue Proteins (metabolism)
  • Neurofibrillary Tangles (metabolism)
  • Plaque, Amyloid (metabolism)
  • Protein Folding
  • Protein Kinases (metabolism)
  • Ubiquitin (metabolism)
  • alpha-Crystallin B Chain
  • tau Proteins (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: