Lymphoma with large-plaque parapsoriasis treated with PUVA.

Abstract

We report on a 78-year-old Japanese woman with a 50-year history of large-plaque parapsoriasis that had evolved into cutaneous T-cell lymphoma. Her large-plaque parapsoriasis had been treated with psoralen plus ultraviolet A for 10 years. Subsequently an isolated nodule appeared on her right lower leg. Prior or concurrent patches or plaques were absent. Histology revealed a diffuse nonepidermotropic infiltrate of large lymphocytes in the dermis, which had enlarged nuclei and prominent nucleoli. A diagnosis of CD30- cutaneous large T-cell lymphoma was made. Following systemic chemotherapy, there was clinical improvement. No evidence of recurrence or systemic lymphoma has subsequently been found.

• Authors: Risa Tamagawa, Norito Katoh, Chihiro Shimazaki, Akira Okano, Shinya Yamada, Kaori Ichihashi, Koji Masuda, Saburo Kishimoto
• Journal: European journal of dermatology : EJD (Eur J Dermatol) 2005 Jul-Aug Vol. 15 Issue 4 Pg. 265-7 ISSN: 1167-1122 [Print] France
• PMID: 16048755 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Diagnosis, Differential
• Female
• Humans
• Lower Extremity
• Lymphoma, T-Cell, Cutaneous (complications, diagnosis, drug therapy, pathology)
• PUVA Therapy
• Psoriasis (complications)
• Skin Neoplasms (complications, diagnosis, drug therapy, pathology)