Intracoronary continuous adenosine infusion.

Abstract

BACKGROUND:

Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined.

METHODS AND RESULTS:

Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured after 3 dosages of IC adenosine infusion (180, 240 and 300 microg/min) in 30 patients. The phase II study was performed to compare the hyperemic efficacy of IC infusion (240 microg/min) with IC bolus injection (40, 80 microg) and intravenous (IV) infusion (140 microg x kg (-1) x min(-1)) of adenosine in 20 patients. In the phase I study, no significant differences in FFR were observed with the 3 different doses of IC infusion (p = 0.06). In the phase II study, FFR after an IC bolus injection (0.83+/-0.06) was significantly higher than with IV (0.79+/-0.07) or IC (0.78+/-0.09) infusion (p < 0.01). However, no difference in FFR was observed for IC and IV infusions.

CONCLUSION:

IC infusion of adenosine seems to be a safe and effective method of inducing maximal hyperemia for FFR measurement.

• Authors: Bon-Kwon Koo, Cheol-Ho Kim, Sang-Hun Na, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi, Hyo-Soo Kim, Myoung-Mook Lee, Byung-Hee Oh, Young-Bae Park, Yun-Shik Choi, Seung-Jae Tahk
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 69 Issue 8 Pg. 908-12 (Aug 2005) ISSN: 1346-9843 [Print] Japan
• PMID: 16041158 (Publication Type: Clinical Trial, Clinical Trial, Phase I, Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adenosine

Topics

• Adenosine (administration & dosage)
• Aged
• Blood Flow Velocity (drug effects)
• Coronary Circulation (drug effects)
• Coronary Stenosis (drug therapy)
• Female
• Humans
• Hyperemia (chemically induced)
• Infusions, Intra-Arterial
• Male
• Middle Aged