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Effects of modified low-density lipoproteins on human retinal pericyte survival.

Abstract
According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G-LDL) and heavily oxidized glycated LDL (HOG-LDL). We demonstrate here that modified LDL inhibits the proliferation and survival of cultured human retinal pericytes. Modified LDL also induced DNA fragmentation in bovine retinal pericytes. Overall, HOG-LDL produced a significantly higher extent of cytotoxicity and apoptosis in retinal pericytes. These results indicate that exposure of pericytes to HOG-LDL could be implicated in the development of diabetic retinopathy.
AuthorsWeiwei Song, Jeremy L Barth, Kangmo Lu, Yongxin Yu, Yan Huang, Cynthia K Gittinger, W Scott Argraves, Timothy J Lyons
JournalAnnals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1043 Pg. 390-5 (Jun 2005) ISSN: 0077-8923 [Print] United States
PMID16037260 (Publication Type: Journal Article)
Chemical References
  • Glycation End Products, Advanced
  • Lipoproteins, LDL
  • glycated lipoproteins, LDL
Topics
  • Apoptosis (drug effects)
  • Cell Survival
  • DNA Fragmentation (drug effects)
  • Glycation End Products, Advanced
  • Humans
  • Lipoproteins, LDL (pharmacology)
  • Pericytes (cytology, drug effects)
  • Retina (cytology)

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