Abstract |
According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins ( LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G- LDL) and heavily oxidized glycated LDL (HOG- LDL). We demonstrate here that modified LDL inhibits the proliferation and survival of cultured human retinal pericytes. Modified LDL also induced DNA fragmentation in bovine retinal pericytes. Overall, HOG- LDL produced a significantly higher extent of cytotoxicity and apoptosis in retinal pericytes. These results indicate that exposure of pericytes to HOG- LDL could be implicated in the development of diabetic retinopathy.
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Authors | Weiwei Song, Jeremy L Barth, Kangmo Lu, Yongxin Yu, Yan Huang, Cynthia K Gittinger, W Scott Argraves, Timothy J Lyons |
Journal | Annals of the New York Academy of Sciences
(Ann N Y Acad Sci)
Vol. 1043
Pg. 390-5
(Jun 2005)
ISSN: 0077-8923 [Print] United States |
PMID | 16037260
(Publication Type: Journal Article)
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Chemical References |
- Glycation End Products, Advanced
- Lipoproteins, LDL
- glycated lipoproteins, LDL
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Topics |
- Apoptosis
(drug effects)
- Cell Survival
- DNA Fragmentation
(drug effects)
- Glycation End Products, Advanced
- Humans
- Lipoproteins, LDL
(pharmacology)
- Pericytes
(cytology, drug effects)
- Retina
(cytology)
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