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Cytological study of copper in oral submucous fibrosis.

AbstractBACKGROUND:
Habitual arecanut chewing is associated with Oral Submucous Fibrosis (OSF). High copper content in arecanut plays a vital role in pathogenesis of OSF. This study evaluates the copper-staining pattern of buccal epithelial cells in oral cytological smears of non-chewers, chewers, and OSF.
MATERIALS & METHODS:
Alcohol fixed buccal epithelial smears of 10 histopathologically confirmed cases of OSF, 10 chewers without lesion, and 5 nonchewers were stained with modified Rhodamine technique and studied under the light microscope. Buccal epithelial smears of non-chewers dipped in copper sulphate solution were used as known positive for copper.
RESULT:
Copper appeared as shades of palered within the cytoplasm of chewers and did not show any stain in non-chewers. Intense red stain was seen in OSF smears as dark granules within the cytoplasm.
CONCLUSION:
Intense staining of copper in OSF buccal smears, than in the chewers supports the role of copper in the pathogenesis of OSF.
AuthorsT Rooban, T R Saraswathi, Antony George, Elizabeth Joshua, K Ranganathan
JournalIndian journal of dental research : official publication of Indian Society for Dental Research (Indian J Dent Res) 2004 Oct-Dec Vol. 15 Issue 4 Pg. 129-32 ISSN: 0970-9290 [Print] India
PMID16035640 (Publication Type: Journal Article)
Chemical References
  • Fluorescent Dyes
  • Rhodamines
  • Copper
Topics
  • Areca
  • Copper (analysis)
  • Cytoplasm (pathology)
  • Epithelial Cells (pathology)
  • Fluorescent Dyes
  • Humans
  • Mouth Mucosa (pathology)
  • Oral Submucous Fibrosis (pathology)
  • Rhodamines

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