Gold trichloride and gold sodium thiosulfate as markers of contact allergy to gold.

Abstract

The usefulness of a trivalent gold salt, gold trichloride (GTC), was evaluated as a marker of contact allergy to gold. Patients patch test-positive or patch test-negative to gold sodium thiosulfate (GSTS), 13 subjects of each, were patch tested with dilution series of GTC and equimolar concentrations of GSTS. In order to avoid false-positive and false-negative test reactions, the salts were buffered and placed on polypropene chambers. Allergic reactions were registered in 9/13 gold-allergic patients with GSTS and in 2/13 with GTC. The sum of positive reactions was 18 with GSTS and 5 with GTC. Irritant reactions were none with GSTS and 2 with GTC in the gold-allergic patients. It is concluded that GTC can elicit positive patch test reactions in patients with gold allergy but to a lesser degree when compared with GSTS. Thus, GTC cannot be recommended in patch testing, and GSTS is still the test agent of choice.

• Authors: Halvor Möller, Ingela Ahnlide, Birgitta Gruvberger, Magnus Bruze
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 53 Issue 2 Pg. 80-3 (Aug 2005) ISSN: 0105-1873 [Print] England
• PMID: 16033400 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gold Compounds
• Gold
• Gold Sodium Thiosulfate

Topics

• Aged
• Dermatitis, Allergic Contact (diagnosis, etiology)
• Female
• Gold (adverse effects)
• Gold Compounds
• Gold Sodium Thiosulfate
• Humans
• Male
• Middle Aged
• Patch Tests