Abstract |
Phorbol esters are chemical compounds which have the ability to promote carcinogenesis in the skin of mice. In the HRA/Skh mouse strain, an initiation-promotion assay substantiated evidence that mezerein acts as a complete promoter. Complete promotion with 9.0 nmol mezerein induced a total of 53 papillomas in 28 mice within 40 weeks, while 1.5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA), using the same application regime, resulted in a total of 298 papillomas in 58 mice. However, 7.6% of the papillomas in the mezerein group progressed to carcinomas, compared with 0.7% in the TPA group. Approximately the same molar concentrations of TPA and mezerein induced a dose-dependent and reproducible increase in micronuclei in supra-basal cells derived from the epidermis of treated mice. In contrast, the latter compound was less toxic to these cells and induced higher numbers of micronuclei at the higher concentrations.
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Authors | H H Steinel, A M Bonin, K Meher-Homji, R S Baker |
Journal | Mutagenesis
(Mutagenesis)
Vol. 7
Issue 3
Pg. 199-203
(May 1992)
ISSN: 0267-8357 [Print] England |
PMID | 1602975
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carcinogens
- Diterpenes
- Terpenes
- mezerein
- Tetradecanoylphorbol Acetate
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Topics |
- Animals
- Carcinogens
(toxicity)
- Diterpenes
- Female
- Keratinocytes
(cytology, drug effects)
- Kinetics
- Mice
- Micronucleus Tests
- Skin Neoplasms
(chemically induced)
- Terpenes
(toxicity)
- Tetradecanoylphorbol Acetate
(pharmacology)
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