Abstract | BACKGROUND: METHODS: A total of 183 ASA I or II in-patients, aged 1-12 years, admitted for unilateral inguinal hernia repair were randomized to receive in a double-blind design either i.v. paracetamol 15 mg.kg(-1) (n = 95) or propacetamol 30 mg.kg(-1) (n = 88) for postoperative pain relief as soon as pain intensity was greater than 30 on a 100 mm visual analog scale. All patients were evaluated for efficacy and tolerance. Efficacy was evaluated between 15 min and 6 h after the start of the 15 min infusion. RESULTS: The most frequently reported adverse event was injection site pain, which was significantly reduced in the new formulation group (i.v. paracetamol 14.7% vs propacetamol 33.0% of children, P = 0.005). No significant difference was obtained between treatments on pain relief (PR), pain intensity difference (PAID) from baseline, and objective pain scale intensity difference (OPSD). Also, treatment effects did not differ significantly for maximum values and weighted sums of PR, PAID (investigator and child rated), OPSD, time to first request for rescue medication, proportion of children requesting rescue medication, and investigators' global treatment satisfaction. CONCLUSION:
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Authors | I Murat, C Baujard, C Foussat, E Guyot, H Petel, B Rod, C Ricard |
Journal | Paediatric anaesthesia
(Paediatr Anaesth)
Vol. 15
Issue 8
Pg. 663-70
(Aug 2005)
ISSN: 1155-5645 [Print] France |
PMID | 16029401
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Non-Narcotic
- Prodrugs
- Acetaminophen
- propacetamol
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Topics |
- Acetaminophen
(administration & dosage, analogs & derivatives)
- Analgesics, Non-Narcotic
(administration & dosage)
- Anesthesia, General
- Child
- Child, Preschool
- Double-Blind Method
- Female
- Hernia, Inguinal
(surgery)
- Humans
- Infant
- Infusions, Intravenous
(adverse effects)
- Male
- Nerve Block
- Pain Measurement
- Pain, Postoperative
(prevention & control)
- Patient Satisfaction
- Prodrugs
(administration & dosage)
- Treatment Outcome
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