Adenocarcinoma of the larynx: a case report with histochemical and immunohistochemical studies.

Abstract

Adenocarcinomas constitute a histologically diverse group of rare laryngeal neoplasms accounting in aggregate for less than 1% of all laryngeal carcinomas. Adenocarcinoma of the larynx "not otherwise specified" (NOS) is a very uncommon neoplasia, but it shows a high degree of malignancy. We report a case of adenocarcinoma "NOS" arising in the larynx of a 60-year-old man. Histologically, the tumor tissue was composed of only adenocarcinoma component. Histochemically, the adenocarcinoma cells demonstrated Alcian blue pH: 2.5 and PAS reactivity, but did not include argentaffin and argyrophil granules. Immunohistochemical studies revealed negative reactivity for desmin, HMB45 and NSE. S-100 and chromogranin was focally positive, cytokeratin was diffusely positive.

• Authors: Irfan Bayram, Serdar Uğraş, Muzaffer Kiriş, Deniz Reçber
• Journal: Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat (Kulak Burun Bogaz Ihtis Derg) Vol. 13 Issue 1-2 Pg. 41-5 ( 2004) ISSN: 1300-7475 [Print] Turkey
• PMID: 16027493 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Adenocarcinoma (diagnosis, pathology, surgery)
• Diagnosis, Differential
• Humans
• Immunohistochemistry
• Laryngeal Neoplasms (diagnosis, pathology, surgery)
• Male
• Middle Aged