Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview.

Abstract

The discovery of a second receptor for prostaglandin D2, chemoattractant receptor-homologous molecule expressed on T helper type 2 (CRTH2), has revived significant efforts into the development of small-molecule antagonists for allergic diseases as the receptor is predominantly expressed on cells such as eosinophils, TH2 cells and basophils, which are major pro-inflammatory cells in diseases such as asthma and allergic rhinitis. This brief review serves to illustrate current patent literature focusing on the similarities and differences of an ever-growing number of CRTH2 antagonists emerging from corporate laboratories.

• Authors: Tai Wei Ly, Kevin B Bacon
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 14 Issue 7 Pg. 769-73 (Jul 2005) ISSN: 1744-7658 [Electronic] England
• PMID: 16022566 (Publication Type: Editorial, Review)

Chemical References

• Inflammation Mediators
• Prostaglandin Antagonists
• Receptors, Immunologic
• Receptors, Prostaglandin
• prostaglandin D2 receptor

Topics

• Animals
• Humans
• Hypersensitivity (drug therapy, immunology, pathology)
• Inflammation Mediators (antagonists & inhibitors, physiology)
• Prostaglandin Antagonists (pharmacology, therapeutic use)
• Receptors, Immunologic (antagonists & inhibitors, physiology)
• Receptors, Prostaglandin (antagonists & inhibitors, physiology)