Abstract | OBJECTIVE: The PTEN tumor suppressor gene has been demonstrated to be inactivated in a variety of human tumors. In breast cancer, the PTEN gene mutation is not commonly found whereas loss of heterozygosity affecting the PTEN locus is frequently found. The aim of this study was to analyze PTEN protein expression in breast cancer and to evaluate the prognostic significance of PTEN protein expression. METHODS: RESULTS: The expression of PTEN protein was found to have decreased in 67 (28%) of 236 breast cancers. The reduced expression correlated with lymph node metastasis (p = 0.0371), but not with tumor size, nuclear grade, MIB-1 counts or p53 protein expression. Univariate analysis indicated that patients with a reduced PTEN expression had a shorter disease-free survival (DFS) than those with a normal PTEN expression (p = 0.0174). Univariate analyses also determined tumor size, lymph node metastases, nuclear grade, MIB-1 counts, p53 protein as well as PTEN protein expression to be significant factors for DFS, while multivariate analysis determined lymph node metastases and the MIB-1 counts to be independent significant factors for DFS. CONCLUSIONS:
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Authors | Shinichi Tsutsui, Hiroshi Inoue, Kazuhiro Yasuda, Kosuke Suzuki, Hidefumi Higashi, Shoichi Era, Masaki Mori |
Journal | Oncology
(Oncology)
Vol. 68
Issue 4-6
Pg. 398-404
( 2005)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 16020969
(Publication Type: Journal Article)
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Copyright | (c) 2005 S. Karger AG, Basel |
Chemical References |
- Biomarkers, Tumor
- Ki-67 Antigen
- Receptors, Estrogen
- Tumor Suppressor Protein p53
- Tumor Suppressor Proteins
- Phosphoric Monoester Hydrolases
- PTEN Phosphohydrolase
- PTEN protein, human
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Breast Neoplasms
(metabolism, pathology)
- Carcinoma, Ductal, Breast
(metabolism, pathology)
- Female
- Humans
- Immunoenzyme Techniques
- Ki-67 Antigen
(metabolism)
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Invasiveness
(pathology)
- Neoplasm Staging
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
(metabolism)
- Prognosis
- Receptors, Estrogen
(metabolism)
- Survival Rate
- Tumor Suppressor Protein p53
(metabolism)
- Tumor Suppressor Proteins
(metabolism)
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