Abstract | OBJECTIVE: DESIGN: Prospective. SETTING: City Maternity Hospital, Helsinki, Finland. PATIENTS: Eleven postmenopausal women used transdermal estradiol (E2) patches for 6 weeks immediately before a vaginal operation for prolapse. For the last 10 days, 1 mg of ST-1435 transdermally in a gel was combined to the treatment. MAIN OUTCOME MEASURES: Blood samples were taken to follow serum concentrations of E2, follicle-stimulating hormone, and ST-1435. Endometrial samples for histologic examination were collected during the operation to evaluate the effect of the progestin. RESULTS: Transdermal absorption of ST-1435 resulted in reasonably constant serum concentrations of ST-1435 in each subject. A progestin effect on the endometrium was seen in 9 of 10 samples obtained. One sample did not show any progestin effect in spite of adequate ST-1435 levels, but this patient's E2 concentrations were low. CONCLUSIONS:
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Authors | S Suhonen, M Haukkamaa, P Lähteenmäki, T Holmström |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 57
Issue 6
Pg. 1211-5
(Jun 1992)
ISSN: 0015-0282 [Print] United States |
PMID | 1601141
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Norprogesterones
- Estradiol
- ST 1435
- Follicle Stimulating Hormone
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Topics |
- Administration, Cutaneous
- Aged
- Endometrium
(drug effects, pathology)
- Estradiol
(blood, therapeutic use)
- Estrogen Replacement Therapy
- Female
- Follicle Stimulating Hormone
(blood)
- Humans
- Middle Aged
- Norprogesterones
(blood, therapeutic use)
- Osmolar Concentration
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