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A genetically engineered strain of Pseudomonas putida as a useful tool for identifying new therapeutic herbicides.

Abstract
A genetically engineered strain of Pseudomonas putida U designed for the identification of new therapeutic herbicides has been obtained. In this bacterium, deletion of the homogentisate gene cluster (hmgRABC) confers upon this mutant huge biotechnological possibilities since it can be used: (i) as a target for testing new specific herbicides (p-hydroxy-phenylpyruvate dioxygenase inhibitors); (ii) to identify new therapeutic drugs-effective in the treatment of alkaptonuria and other related tyrosinemia - and (iii) as a source of homogentisic acid in a plant-bacterium association.
AuthorsElsa Arias-Barrau, Angel Sandoval, Mario Arcos, Sagrario Arias, Germán Naharro, Elías R Olivera, José M Luengo
JournalFEMS microbiology letters (FEMS Microbiol Lett) Vol. 249 Issue 2 Pg. 297-302 (Aug 15 2005) ISSN: 0378-1097 [Print] England
PMID16006061 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA Primers
  • Herbicides
Topics
  • Amino Acid Sequence
  • Base Sequence
  • Biotechnology (methods)
  • Chromatography, High Pressure Liquid
  • DNA Primers
  • Genetic Engineering (methods)
  • Herbicides (pharmacology)
  • Molecular Sequence Data
  • Multigene Family
  • Mutagenesis
  • Pseudomonas putida (drug effects, genetics)
  • Restriction Mapping

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