Markers of malignant transformation of sinonasal inverted papilloma.

Abstract

AIM:

To measure HPV status, epidermal growth factor receptor (EGFR) and transforming growth factor-alpha (TGF-alpha) expression and Ki-67 index in exophytic papilloma (EP), inverted papilloma (IP) with dysplasia, IP with carcinoma and invasive squamous cell carcinoma (SCC).

METHODS:

Forty-four patients with sinonasal papilloma and invasive SCC were selected. The nasal tissues were stained with monoclonal antibodies to EGFR, TGF-alpha and Ki-67. The results were analysed using quantitative immunohistochemical analysis. In situ hybridization studies for HPV DNA for 6/11, 16/18 and 31/33 were also performed on the tissue.

RESULTS:

Significant increase of EGFR and TGF-alpha was observed in IP with severe dysplasia, IP with carcinoma and invasive SCC compared to IP with mild dysplasia and control nasal mucosa. And a serial upreguration in terms of Ki-67 index in IP with dysplasia was observed. Among IP, HPV 6/11-positive was present in 42% tumour and HPV 16/18-positive was present in 31% of tumours. Among HPV 6/11 and 16/18-positive IP, significant increase of EGFR and Ki-67 index were observed.

CONCLUSION:

Pre-cancerous lesions of IP exhibited elevated levels of EGFR and TGF-alpha and these expression may be associated with early events in IP carcinogenesis. HPV infection may be an early event in a multistep process of malignant formation of IP.

• Authors: H Katori, A Nozawa, M Tsukuda
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 31 Issue 8 Pg. 905-11 (Oct 2005) ISSN: 0748-7983 [Print] England
• PMID: 16005600 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Biomarkers, Tumor
• Ki-67 Antigen
• Transforming Growth Factor alpha
• ErbB Receptors

Topics

• Antibodies, Monoclonal
• Biomarkers, Tumor (analysis)
• Carcinoma (pathology)
• Carcinoma, Squamous Cell (pathology)
• Cell Transformation, Neoplastic (pathology)
• ErbB Receptors (analysis)
• Female
• Humans
• In Situ Hybridization
• Ki-67 Antigen (analysis)
• Male
• Middle Aged
• Nasal Mucosa (pathology)
• Neoplasm Invasiveness
• Nose Neoplasms (pathology)
• Papilloma (pathology)
• Papilloma, Inverted (pathology)
• Papillomaviridae (classification, isolation & purification)
• Paranasal Sinus Neoplasms (pathology)
• Precancerous Conditions (pathology)
• Transforming Growth Factor alpha (analysis)