[Intraarterial concomitant chemoradiation for tongue cancer: analysis of 20 patients].

Abstract

Subjects were 20 patients with tongue cancer treated between April 1996 and December 2002 with intraarterial infusion of cisplatin (60-120 mg/m2) (and docetaxel 10-30 mg/m2) and intravenous infusion of sodium thiosulfate followed by 5-fluorouracil (5-FU) (800-1000 mg/m2) for 3 to 5 days. All patients underwent radiation (50-80 Gy). Ten had stage II, 4 stage III, and 6 stage IV A disease. Complete response at the primary site was achieved in 50% for T2, 67% for T3, and 0% for T4 lesions in those undergoing IA cisplatin followed by systemic 5-FU with concurrent radiation. Complete response at the primary site was achieved in all patients given IA cisplatin and docetaxel followed by systemic 5-FU with concurrent radiation. Disease-specific survival was 75% and overall survival 69% at 5 years. Side effects of treatment were tolerable, except for grade three radiomucositis in 70% of patients and grade three bone marrow depression in one treated with weekly IA chemotherapy.

• Authors: Sohei Endo, Shin Suzuki, Kenzo Tsuji, Hideo Niwa, Yugo Noguchi, Kenji Yoshida, Akinori Kida, Yoshiaki Tanaka, Kazuhisa Himi, Akiko Takemoto
• Journal: Nihon Jibiinkoka Gakkai kaiho (Nihon Jibiinkoka Gakkai Kaiho) Vol. 108 Issue 6 Pg. 689-93 (Jun 2005) ISSN: 0030-6622 [Print] Japan
• PMID: 16001727 (Publication Type: Journal Article)

Chemical References

• Taxoids
• Thiosulfates
• Docetaxel
• sodium thiosulfate
• Cisplatin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Docetaxel
• Female
• Fluorouracil (administration & dosage)
• Humans
• Infusions, Intra-Arterial
• Male
• Middle Aged
• Prognosis
• Retrospective Studies
• Taxoids (administration & dosage)
• Thiosulfates (administration & dosage)
• Tongue Neoplasms (drug therapy, radiotherapy)