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Lactobacillus paracasei strain ST11 has no effect on rotavirus but ameliorates the outcome of nonrotavirus diarrhea in children from Bangladesh.

AbstractBACKGROUND:
Previous studies have shown that selected strains of lactobacilli that are administered orally result in a modest reduction of diarrhea duration. However, duration alone is not considered optimal for therapeutic evaluation of any agent in diarrhea.
OBJECTIVE:
To examine the effect of a new probiotic, Lactobacillus paracasei strain ST11 (ST11), in acute childhood diarrhea by using evaluation criteria recommended by the World Health Organization.
METHODS:
In a randomized, double-blind, placebo-controlled clinical trial, 230 male infants and young children, 4 to 24 months of age, presenting with diarrhea of <2 days' duration were admitted to the metabolic research ward of the International Centre for Diarrheal Disease Research, Bangladesh, and fed 10(10) colony-forming units of lyophilized ST11 or placebo daily for 5 days. Stool output and frequency, oral rehydration solution intake, and excretion of rotavirus were monitored daily.
RESULTS:
No effect of ST11 treatment on severe rotavirus diarrhea was observed. However, the probiotic treatment did significantly reduce cumulative stool output (225 +/- 218 vs 381 +/- 240 mL/kg), stool frequency (27.9 +/- 17 vs 42.5 +/- 26), and oral rehydration solution intake (180 +/- 207 vs 331 +/- 236 mL/kg) in children with less-severe nonrotavirus diarrhea compared with those receiving placebo treatment. A significantly higher proportion of nonrotavirus children receiving ST11 had their diarrhea resolve within 6 days of therapy (ST11 versus placebo: 76% vs 49%).
CONCLUSIONS:
ST11 has a clinically significant benefit in the management of children with nonrotavirus-induced diarrhea, but it is ineffective in those with rotavirus diarrhea.
AuthorsShafiqul A Sarker, Shamima Sultana, George J Fuchs, Nur H Alam, Tasnim Azim, Harald Brüssow, Lennart Hammarström
JournalPediatrics (Pediatrics) Vol. 116 Issue 2 Pg. e221-8 (Aug 2005) ISSN: 1098-4275 [Electronic] United States
PMID15995003 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Topics
  • Bangladesh
  • Diarrhea, Infantile (therapy, virology)
  • Double-Blind Method
  • Feces (microbiology, virology)
  • Humans
  • Infant
  • Lactobacillus
  • Male
  • Probiotics (therapeutic use)
  • Rotavirus (isolation & purification)
  • Rotavirus Infections (therapy)

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