HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Studies on post-transplant dyslipidemia in kidney transplant patients.

Abstract
This study was performed to retrospectively compare changes in the levels of total cholesterol, non-HDL cholesterol, triglycerides, and immunosuppressive drugs, cyclosporine A and steroids in patients with living-relation renal transplants with those from non-heart-beating donors. We experienced 11 cases of kidney transplants from non-heart-beating donors during the period from April 1995 to May 2003. We evaluated 13 cases of kidney transplants from living-relation donors during the same period. The immunosuppressants used included mainly cyclosporine A as well as mycophenolate mofetil or azathioprine, steroid and ALG, or basiliximab. Over-night fasting lipids (total cholesterol, triglycerides and HDL cholesterol) were studied before renal transplantation and repeated after renal transplantation at 1, 3, 6 and 12 months. The levels of total cholesterol and triglycerides remained in the normal range before transplantation. However, the levels of total cholesterol increased siginificantly 1 and 3 months after transplantation from non-heart-beating donors and remained at higher levels up to 12 months after transplantation. A similar pattern in the levels of triglycerides was observed. The levels of HDL cholesterol remained unchanged and stayed in the normal range before and 1, 3, 6, and 12 months after transplantation from non-heart-beating donors. On the other hand, significant increases in non-HDL cholesterol were observed 3 and 6 months after transplantation from non-heart-beating donors. After transplantation from living-relation donors, levels of total cholesterol, triglycerides, and non-HDL cholesterol remained unchanged and remained in the normal range up to 12 months after transplantation. Although there were no significant differences in the total dosage of cyclosporine A between the patients with living-relation donors and those with non-heart-beating donors, a significant increase in the total dosage of methylprednisolone was observed in patients with non-heart-beating donors compared with those in the patients with living-relation donors. Renal function recovery in patients with living-relation donors was better than in those with non-heart-beating donors. These results may suggest that significant increases in total cholesterol, especially non-HDL cholesterol and triglycerides, were probably partly due to an increased use of immunosuppressants, steroids. It is necessary to aggressively control post-transplant hyperlipidemia and important to reduce or withdraw steroids in the selected, low-risk recipients as early as possible from the viewpoint of preventing post-transplant hyperlipidemia.
AuthorsSeiji Marubayashi, Hideki Ohdan, Hirotaka Tashiro, Daisuke Tokita, Takashi Onoe, Keisuke Hayamizu, Toshimasa Asahara, Shigehiro Doi, Satoshi Okumoto, Chie Tanji, Tohru Kawai, Yoshihiko Taniguchi, Yasuhiko Fukuda, Kiyohiko Dohi
JournalHiroshima journal of medical sciences (Hiroshima J Med Sci) Vol. 54 Issue 2 Pg. 39-45 (Jun 2005) ISSN: 0018-2052 [Print] Japan
PMID15991596 (Publication Type: Journal Article)
Chemical References
  • Cholesterol, HDL
  • Triglycerides
  • Cyclosporine
  • Cholesterol
  • Methylprednisolone
Topics
  • Adult
  • Cholesterol (blood)
  • Cholesterol, HDL (blood)
  • Cyclosporine (adverse effects)
  • Female
  • Humans
  • Hyperlipidemias (etiology)
  • Kidney Transplantation (adverse effects)
  • Male
  • Methylprednisolone (adverse effects)
  • Middle Aged
  • Retrospective Studies
  • Triglycerides (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: