Sex differences in cell death.

Abstract	Female patients experience substantial neuroprotection after experimental stroke compared with male patients, a finding attributed to the protective effects of gonadal hormones. This study examined the response of male- and female-derived organotypic hippocampal slices to oxidative and excitotoxic injury. Both oxygen and glucose deprivation and N-methyl-D-aspartic acid exposure led to neuronal death; however, female-derived cultures sustained less injury than male-derived cultures. Cell death after oxygen and glucose deprivation was ameliorated in male cultures, but not female cultures, by the addition of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor. These studies have relevance to researchers investigating neuroprotective agents in mixed sex experiments.
Authors	Hong Li, Scott Pin, Zhiyuan Zeng, Michael M Wang, Katrin A Andreasson, Louise D McCullough
Journal	Annals of neurology (Ann Neurol) Vol. 58 Issue 2 Pg. 317-21 (Aug 2005) ISSN: 0364-5134 [Print] United States
PMID	15988750 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	DNA-Binding Proteins High Mobility Group Proteins Indazoles Neuroprotective Agents RNA, Messenger SOXB1 Transcription Factors Transcription Factors Nitric Oxide N-Methylaspartate Superoxide Dismutase Glucose 7-nitroindazole
Topics	Animals Animals, Newborn Cell Death (drug effects, physiology) DNA-Binding Proteins (genetics) Disease Models, Animal Drug Interactions Female Genotype Glucose (deficiency) High Mobility Group Proteins (genetics) Hippocampus (pathology) Hypoxia Indazoles (therapeutic use) Male N-Methylaspartate (toxicity) Neurons (drug effects, pathology) Neuroprotective Agents (therapeutic use) Nitric Oxide (metabolism) Organ Culture Techniques RNA, Messenger (biosynthesis) Rats Reverse Transcriptase Polymerase Chain Reaction (methods) SOXB1 Transcription Factors Sex Characteristics Stroke (etiology, pathology, prevention & control) Superoxide Dismutase (metabolism) Time Factors Transcription Factors (genetics)

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