Abstract |
The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P=0.03; rs363333, P=0.0066) as well as for several haplotypes (minimal P=0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P=0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P=0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence.
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Authors | Sibylle G Schwab, Petra E Franke, Barbara Hoefgen, Vera Guttenthaler, Dirk Lichtermann, Matyas Trixler, Michael Knapp, Wolfgang Maier, Dieter B Wildenauer |
Journal | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
(Neuropsychopharmacology)
Vol. 30
Issue 12
Pg. 2263-8
(Dec 2005)
ISSN: 0893-133X [Print] England |
PMID | 15988470
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Genetic Markers
- SLC18A2 protein, human
- Vesicular Monoamine Transport Proteins
- DNA
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Topics |
- Adult
- Aged
- Alcoholism
(epidemiology, genetics, psychology)
- DNA
(genetics)
- Female
- Genetic Markers
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
(genetics)
- Male
- Middle Aged
- Polymorphism, Genetic
(genetics)
- Psychiatric Status Rating Scales
- Sex Characteristics
- Tobacco Use Disorder
(epidemiology, genetics, psychology)
- Vesicular Monoamine Transport Proteins
(genetics)
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