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Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence.

Abstract
The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P=0.03; rs363333, P=0.0066) as well as for several haplotypes (minimal P=0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P=0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P=0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence.
AuthorsSibylle G Schwab, Petra E Franke, Barbara Hoefgen, Vera Guttenthaler, Dirk Lichtermann, Matyas Trixler, Michael Knapp, Wolfgang Maier, Dieter B Wildenauer
JournalNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology) Vol. 30 Issue 12 Pg. 2263-8 (Dec 2005) ISSN: 0893-133X [Print] England
PMID15988470 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Genetic Markers
  • SLC18A2 protein, human
  • Vesicular Monoamine Transport Proteins
  • DNA
Topics
  • Adult
  • Aged
  • Alcoholism (epidemiology, genetics, psychology)
  • DNA (genetics)
  • Female
  • Genetic Markers
  • Genotype
  • Haplotypes
  • Humans
  • Linkage Disequilibrium (genetics)
  • Male
  • Middle Aged
  • Polymorphism, Genetic (genetics)
  • Psychiatric Status Rating Scales
  • Sex Characteristics
  • Tobacco Use Disorder (epidemiology, genetics, psychology)
  • Vesicular Monoamine Transport Proteins (genetics)

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