Abstract | BACKGROUND: The majority of vascular anomalies can be diagnosed accurately based on natural history and physical examination; however, there is no convenient, noninvasive, and objective method to (1) differentiate hemangioma from vascular malformation; (2) determine whether a hemangioma is in the proliferating or involuting phase; (3) tell whether or not corticosteroids or interferon alfa-2a is effective for hemangioma; or (4) follow up hemangioma. Although the differences in endothelial cell, protein, and mRNA expression levels of some positive and negative angiogenic factors in the lesions can help to solve these problems, these methods (pathological section, immunohistochemical analysis, and in situ hybridization techniques) necessitate that a biopsy be performed, and the procedures are complicated. A nonsurgical and convenient method would have significant clinical applications. METHODS: RESULTS: CONCLUSIONS:
|
Authors | Li Zhang, Xiaoxi Lin, Wei Wang, Xing Zhuang, Jiasheng Dong, Zuoliang Qi, Qionghua Hu |
Journal | Plastic and reconstructive surgery
(Plast Reconstr Surg)
Vol. 116
Issue 1
Pg. 200-4
(Jul 2005)
ISSN: 1529-4242 [Electronic] United States |
PMID | 15988268
(Publication Type: Journal Article)
|
Chemical References |
- Vascular Endothelial Growth Factor A
|
Topics |
- Blood Vessels
(abnormalities)
- Capillaries
(abnormalities)
- Cardiovascular Abnormalities
(diagnosis)
- Child, Preschool
- Diagnosis, Differential
- Enzyme-Linked Immunosorbent Assay
- Hemangioma
(diagnosis)
- Humans
- Infant
- Infant, Newborn
- Vascular Endothelial Growth Factor A
(blood)
|