Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel syndrome. A multicenter randomized open trial.

Abstract

The effects of partially hydrolyzed guar gum (PHGG) were compared in patients with irritable bowel syndrome, at 10 g/day (N = 40) and 5 g/day (N = 46) for 12 weeks. Gastrointestinal symptoms (GSRS), quality of life (SF-36), and psychological symptoms (HADS) were evaluated at baseline, during treatment (months 1 and 3), and at follow-up (month 6). In both groups symptoms and quality of life improved significantly after the first month of administration until follow-up compared to those at baseline. However, the improvement was significantly reduced at follow-up compared to the end of treatment. PHGG was effective for improving somatic (gastrointestinal symptoms) and psychological (quality of life and psychological distress) symptoms over the short term. Since the improvement tended to decrease after the end of the treatment period, further studies should evaluate the benefits of PHGG at a maintenance dosage.

• Authors: Giancarlo Parisi, Enrico Bottona, Maurizio Carrara, Fabrizio Cardin, Alessandra Faedo, Dario Goldin, Marco Marino, Maurizio Pantalena, Gianni Tafner, Giorgio Verdianelli, Maurizio Zilli, Gioacchino Leandro
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 50 Issue 6 Pg. 1107-12 (Jun 2005) ISSN: 0163-2116 [Print] United States
• PMID: 15986863 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Fiber
• Galactans
• Mannans
• Plant Gums
• guar gum

Topics

• Adult
• Dietary Fiber (therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Galactans (therapeutic use)
• Health Status Indicators
• Humans
• Irritable Bowel Syndrome (drug therapy, psychology)
• Male
• Mannans (therapeutic use)
• Middle Aged
• Plant Gums
• Quality of Life
• Treatment Outcome