Abstract | BACKGROUND: A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain. METHODS: RESULTS: A reduction in pain scores of 1.1-1.5 units was observed in all groups, and there was no difference between groups. Blood concentrations revealed no significant systemic absorption. Minimal side effects were encountered. CONCLUSION: This randomized, placebo-controlled trial examining topical 2% amitriptyline, 1% ketamine, and a combination in the treatment of neuropathic pain revealed no difference between groups. Optimization of doses may be required, because another study has revealed that higher concentrations of these agents combined do produce significant analgesia.
|
Authors | Mary E Lynch, Alexander J Clark, Jana Sawynok, Michael J L Sullivan |
Journal | Anesthesiology
(Anesthesiology)
Vol. 103
Issue 1
Pg. 140-6
(Jul 2005)
ISSN: 0003-3022 [Print] United States |
PMID | 15983466
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Administration, Topical
- Adult
- Aged
- Aged, 80 and over
- Amitriptyline
(administration & dosage, blood)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Ketamine
(administration & dosage, blood)
- Male
- Middle Aged
- Pain
(blood, drug therapy)
- Polyneuropathies
(blood, drug therapy)
- Syndrome
|