Expression patterns of markers for type II pneumocytes in pulmonary sclerosing hemangiomas and fetal lung tissues.
Abstract | CONTEXT: Although the histogenesis of sclerosing hemangioma is currently not well understood, the tumor has been characterized by its 2 histologically different types of cells, namely, surface and polygonal cells. OBJECTIVE: To elucidate the origin of these cells, we analyzed samples from 15 cases of sclerosing hemangioma and 15 specimens of fetal lung tissue. DESIGN: We immunostained specimens from 15 cases of sclerosing hemangioma and 15 samples of fetal lung tissue using antibodies against thyroid transcription factor 1, MUC1, Thomsen-Friedenreich antigen, and CD44v6, known as markers for type II pneumocytes, and a panel of antibodies against cytokeratin, epithelial membrane antigen, synaptophysin, CD56, estrogen receptor, and progesterone receptor. RESULTS: CONCLUSIONS: Our results suggest that the 2 types of cells in sclerosing hemangioma may derive from a common precursor cell through divergent differentiation toward the type II pneumocyte during tumorigenesis.
|
Authors | Seong Ho Yoo, Kyeong Cheon Jung, Joo Hyun Kim, Sook Whan Sung, Jin-Haeng Chung, Young Soo Shim, Soong Deok Lee, Doo Hyun Chung |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 129
Issue 7
Pg. 915-9
(Jul 2005)
ISSN: 1543-2165 [Electronic] United States |
PMID | 15974816
(Publication Type: Journal Article)
|
Chemical References |
- Antigens
- Antigens, Neoplasm
- Antigens, Tumor-Associated, Carbohydrate
- CD44v6 antigen
- Genetic Markers
- Glycoproteins
- Hyaluronan Receptors
- MUC1 protein, human
- Mucin-1
- Mucins
- NKX2-1 protein, human
- Nuclear Proteins
- Thyroid Nuclear Factor 1
- Transcription Factors
- Thomsen-Friedenreich antigen
|
Topics |
- Adult
- Aged
- Antigens
(genetics, immunology)
- Antigens, Neoplasm
- Antigens, Tumor-Associated, Carbohydrate
(genetics, immunology)
- Female
- Fetus
(chemistry, metabolism)
- Gene Expression Profiling
(methods)
- Gene Expression Regulation, Developmental
(genetics)
- Gene Expression Regulation, Neoplastic
(genetics)
- Genetic Markers
(genetics)
- Glycoproteins
(genetics, immunology)
- Humans
- Hyaluronan Receptors
(genetics, immunology)
- Immunohistochemistry
(methods)
- Lung
(chemistry, embryology, metabolism)
- Middle Aged
- Mucin-1
- Mucins
- Nuclear Proteins
(genetics, immunology)
- Pulmonary Sclerosing Hemangioma
(classification, pathology)
- Thyroid Nuclear Factor 1
- Transcription Factors
(genetics, immunology)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|