Abstract | OBJECTIVE: DESIGN: Prospective, descriptive study. Prospective evaluation of airway function and lung mechanics during and after ECMO by pulmonary function testing at 1.8 +/- 0.5 days of EMCO (period 1), follow-up at 1.4 +/- 0.2 days (period 2), and 7.0 +/- 0.9 days (period 3) after decannulation from ECMO. SETTING: Tertiary care neonatal/pediatric ICU. PATIENTS: INTERVENTIONS: Maximum expiratory flow-volume curves were studied with the deflation flow-volume curve technique, and compliance and resistance of the respiratory system were studied with partial passive flow-volume curves. MEASUREMENTS AND MAIN RESULTS: Respiratory system compliance was the only index of respiratory mechanics that was significantly (p less than .05) improved (0.96 +/- 0.1 vs. 0.61 +/- 0.1 mL/cm H2O/kg) immediately after decannulation from ECMO compared with period 1. Clinically important (p less than .05) improvement in forced vital capacity (28.0 +/- 5.5 vs. 16.1 +/- 1.9 mL/kg), respiratory system compliance (1.01 +/- 0.2 vs. 0.61 +/- 0.1 mL/cm H2O/kg), and maximum expiratory flow at 25%/forced vital capacity (1.0 +/- 0.3 vs. 2.2 +/- 0.3) was evident only during period 3 compared with period 1. CONCLUSIONS: We conclude that improvements in the clinical condition and oxygenation, permitting successful decannulation from ECMO, are achieved before clinically important improvements in lung mechanics.
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Authors | A C Koumbourlis, E K Motoyama, R L Mutich, D K Nakayama, A E Thompson |
Journal | Critical care medicine
(Crit Care Med)
Vol. 20
Issue 6
Pg. 751-6
(Jun 1992)
ISSN: 0090-3493 [Print] United States |
PMID | 1597027
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Acute Disease
- Airway Resistance
(physiology)
- Extracorporeal Membrane Oxygenation
- Female
- Humans
- Infant, Newborn
- Male
- Meconium Aspiration Syndrome
(epidemiology, physiopathology, therapy)
- Prospective Studies
- Pulmonary Ventilation
(physiology)
- Respiratory Function Tests
(statistics & numerical data)
- Respiratory Mechanics
(physiology)
- Time Factors
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