Abstract | BACKGROUND: OBJECTIVE: The present study was designed to examine the effects of allergen sensitization and challenge on the SP/NKA expression in the jugular-nodose ganglion neurons innervating the murine airways. METHODS: Using retrograde neuronal tracing technique in combination with double-labelling immunohistochemistry, the expression of SP/NKA was investigated in a murine model of allergic airway inflammation. RESULTS: Allergic airway inflammation was found to induce the expression of SP/NKA (13.2+/-1.43% vs. 5.8+/-0.37%, P<0.01) in large-diameter (>20 microm) vagal sensory neurons retrograde labelled with Fast blue dye from the main stem bronchi. CONCLUSION: Based on the induction of tachykinins in airway-specific large-sized jugular-nodose ganglia neurons by allergic airway inflammation, the present study suggests that allergen sensitization and challenge may lead to de novo induction of tachykinins in neurons. This may partly contribute to the pathogenesis of airways diseases such as allergic airway inflammation.
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Authors | Q T Dinh, E Mingomataj, D Quarcoo, D A Groneberg, C Witt, B F Klapp, A Braun, A Fischer |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 35
Issue 6
Pg. 820-5
(Jun 2005)
ISSN: 0954-7894 [Print] England |
PMID | 15969675
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Allergens
- Tachykinins
- Substance P
- Neurokinin A
- Ovalbumin
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Topics |
- Allergens
(immunology)
- Animals
- Bronchoalveolar Lavage Fluid
(immunology)
- Cell Differentiation
- Disease Models, Animal
- Female
- Immunohistochemistry
(methods)
- Leukocyte Count
- Mice
- Mice, Inbred BALB C
- Neurokinin A
(immunology)
- Neurons, Afferent
(immunology)
- Ovalbumin
(immunology)
- Respiratory Hypersensitivity
(immunology)
- Substance P
(immunology)
- Tachykinins
(immunology)
- Vagus Nerve
(immunology)
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