Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart.

Abstract

The ability of MnCl2 to enhance canine myocardium and to delineate ischemic areas is demonstrated. A dose-response curve was measured using T1 weighted images in 11 dogs. MnCl2 (36, 113, 360, and 3600 micromol) was infused over a period of 3 min. Signal intensity increased linearly with MnCl2 dose. At 113 micromol ( approximately 10 micromol/kg) the steady-state increase in intensity averaged 212 +/- 34%. No significant physiologic effects due to the infused MnCl2 were detected except at the highest dose where there was a cardiac depressive effect. Ischemia was induced by occluding the left anterior descending coronary artery in 5 dogs. At an infused dose of 113 micromol, MnCl2 clearly demarcated the ischemic zone during coronary occlusion. Contrast enhancement in the ischemic zone was less than 30% compared with normal tissue (P < 0.03). In conclusion, the intracellular contrast agent MnCl2 enhances the canine heart and shows promise in detecting ischemia at doses that do not cause adverse cardiac effects.

• Authors: Tom C-C Hu, Timothy F Christian, Anthony H Aletras, Joni L Taylor, Alan P Koretsky, Andrew E Arai
• Journal: Magnetic resonance in medicine (Magn Reson Med) Vol. 54 Issue 1 Pg. 196-200 (Jul 2005) ISSN: 0740-3194 [Print] United States
• PMID: 15968667 (Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, U.S. Gov't, P.H.S., Validation Study)

Chemical References

• Contrast Media
• Magnesium Chloride

Topics

• Animals
• Contrast Media
• Dogs
• Dose-Response Relationship, Drug
• Heart Ventricles (drug effects, pathology)
• Image Enhancement (methods)
• Infusions, Intra-Arterial
• Magnesium Chloride (administration & dosage)
• Magnetic Resonance Imaging (methods)
• Myocardial Ischemia (complications, pathology)
• Reference Values
• Reproducibility of Results
• Sensitivity and Specificity
• Ventricular Dysfunction, Left (etiology, pathology)