Hyperbaric oxygen as an adjunctive treatment for zygomycosis.

Abstract

Zygomycosis is a rare but emerging mycosis. Because of the sub-optimal efficacy of the standard antifungal treatment for this disease, hyperbaric oxygen (HBO) has been used occasionally as an adjunctive therapeutic modality. A review of 28 published cases of zygomycosis indicates that adjunctive HBO may be beneficial in diabetic patients (94% survival), whereas its benefit in the small group of patients with haematological malignancies or bone marrow transplants is doubtful (33% survival; p 0.02). Prolonged courses of HBO were associated with a higher survival (100% survival; p 0.003). Additional studies are required to assess the optimal timing and dose for HBO treatment.

• Authors: B V John, G Chamilos, D P Kontoyiannis
• Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (Clin Microbiol Infect) Vol. 11 Issue 7 Pg. 515-7 (Jul 2005) ISSN: 1198-743X [Print] England
• PMID: 15966968 (Publication Type: Editorial, Review)

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Diabetes Complications (therapy)
• Hematologic Neoplasms (complications, microbiology)
• Humans
• Hyperbaric Oxygenation
• Infant
• Male
• Middle Aged
• Mucorales
• Treatment Outcome
• Zygomycosis (complications, therapy)