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[Macrophage activation syndrome after treatment with infliximab for fistulated Crohn's disease].

AbstractINTRODUCTION:
Macrophage activation syndrome has never been reported as an adverse effect of infliximab.
CASE:
Treatment with infliximab was prescribed for a 37-year-old man with fistulated Crohn's disease unresponsive to azathioprine. Three months after the last injection, he developed macrophagic activation syndrome, with febrile pancytopenia, hyperferritinemia, hypertriglyceridemia and an activated cephalin time twice the control level.
DISCUSSION:
Elimination of the known causes of macrophage activation syndrome suggests it is related to the infliximab treatment, but its pathogenesis remains a mystery.
AuthorsEric Chauveau, François Terrier, Didier Casassus-Buihle, Xavier Moncoucy, Bernard Oddes
JournalPresse medicale (Paris, France : 1983) (Presse Med) Vol. 34 Issue 8 Pg. 583-4 (Apr 23 2005) ISSN: 0755-4982 [Print] France
Vernacular TitleSyndrome d'activation macrophagique après traitement par infliximab pour maladie de Crohn fistulisée.
PMID15962497 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Gastrointestinal Agents
  • Ferritins
  • Infliximab
Topics
  • Adult
  • Antibodies, Monoclonal (administration & dosage, adverse effects, pharmacology, therapeutic use)
  • Blood Coagulation Disorders (chemically induced)
  • Crohn Disease (drug therapy)
  • Ferritins (blood)
  • Gastrointestinal Agents (administration & dosage, adverse effects, pharmacology, therapeutic use)
  • Humans
  • Hypertriglyceridemia (chemically induced)
  • Infliximab
  • Macrophage Activation (drug effects)
  • Male
  • Pancytopenia (chemically induced)
  • Phagocytosis
  • Syndrome

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