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A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis.

Abstract
Ten patients with human T-cell lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) were treated in an uncontrolled preliminary trial by oral administration of viable Lactobacillus casei strain Shirota (LcS) containing fermented milk. HTLV-1 provirus load, motor function, neurological findings, and immunological parameters were evaluated after 4 weeks. Although LcS did not change the frequencies or absolute numbers of all the examined cell surface phenotypes of peripheral blood mononuclear cells, NK cell activity was significantly increased after 4 weeks of oral administration of LcS preparation. Improvements in spasticity (modified Ashworth Scale scores) and urinary symptoms were also seen after LcS treatment. No adverse effect was observed in all the 10 patients throughout the study period. Our results indicated that LcS may be a safe and beneficial agent for the treatment of HAM/TSP; therefore randomized controlled studies are warranted.
AuthorsToshio Matsuzaki, Mineki Saito, Koichiro Usuku, Hirohisa Nose, Shuji Izumo, Kimiyoshi Arimura, Mitsuhiro Osame
JournalJournal of the neurological sciences (J Neurol Sci) Vol. 237 Issue 1-2 Pg. 75-81 (Oct 15 2005) ISSN: 0022-510X [Print] Netherlands
PMID15961107 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Deltaretrovirus Antibodies
Topics
  • Adult
  • Animals
  • Deltaretrovirus Antibodies (analysis)
  • Disability Evaluation
  • Female
  • Fermentation
  • Flow Cytometry
  • Humans
  • Killer Cells, Natural (immunology)
  • Lacticaseibacillus casei
  • Lymphocyte Count
  • Lymphocytes (immunology)
  • Male
  • Middle Aged
  • Milk (microbiology)
  • Muscle Spasticity (etiology, physiopathology)
  • Paraparesis, Tropical Spastic (immunology, physiopathology, therapy)
  • Phenotype
  • Probiotics (adverse effects, therapeutic use)
  • Prospective Studies
  • Urination Disorders (etiology, physiopathology)
  • Viral Load

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